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Am J Ophthalmol. 2006 Sep;142(3):419-28.

Risk factors for five-year incident age-related macular degeneration: the Reykjavik Eye Study.

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1
Department of Ophthalmology, University of Iceland, Reykjavik, Iceland.

Abstract

PURPOSE:

To establish risk factors for five-year incidence of age-related macular degeneration (AMD).

DESIGN:

Population-based, prospective cohort study, and risk analysis.

METHODS:

A random sample from the Reykjavik Population Census for individuals 50 years and older was selected. We took fundus stereo color photographs and used standard grading system to study the five-year incidence of drusen, pigmentary abnormalities, and AMD and to examine possible risk factors. A questionnaire including information on disease, medication, diet, and lifestyle from the Reykjavik Eye Study database provided additional information.

RESULTS:

Current alcohol consumption decreased the risk for drusen. Being married rather than divorced or widowed decreased the risk for soft drusen; being single decreased the risk of hypopigmentation as compared with being divorced or married. Both consuming dietary fiber-rich vegetables and meat and meat products once a week or less frequently was a risk factor for developing soft drusen and decreased the risk of pigmentary abnormalities. Those who had smoked 20 pack-years or more as compared with nonsmokers had decreased survival rate over the five years (odds ratio (OR) 0.46, 95% confidence interval (CI) 0.27 to 0.80; P = .006).

CONCLUSIONS:

Risk factors for drusen appear to differ from risk factors for pigmentary abnormalities. The effect of smoking on developing AMD is partly masked by selective mortality.

PMID:
16935586
DOI:
10.1016/j.ajo.2006.04.015
[Indexed for MEDLINE]
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