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PLoS Pathog. 2006 Aug;2(8):e79.

KIR/HLA pleiotropism: protection against both HIV and opportunistic infections.

Author information

1
Laboratory of Genomic Diversity, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland, USA.

Abstract

The compound genotype KIR3DS1/HLA-B Bw4-80I, which presumably favors natural killer cell activation, has been implicated in protection against HIV disease. We show that this genotype confers dual protection over the course of HIV disease; early direct containment of HIV viral load, and late specific defense against opportunistic infections, but not AIDS-related malignancies. The double protection of KIR3DS1/Bw4-80I in an etiologically complex disease such as AIDS, along with the disease specificity of its effects is conceptually novel and underscores the intricacy of host immunogenetics against HIV/AIDS.

PMID:
16933987
PMCID:
PMC1550271
DOI:
10.1371/journal.ppat.0020079
[Indexed for MEDLINE]
Free PMC Article
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