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Nat Rev Immunol. 2006 Sep;6(9):682-92.

Tissue-tropic effector T cells: generation and targeting opportunities.

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1
Immunology Section, Lund University, BMC I13, 22184 Lund, Sweden. william.agace@med.lu.se

Abstract

The localization of effector T cells to extralymphoid tissues is crucial for the generation of an effective immune response, but it also underlies many autoimmune and inflammatory disorders. Recent studies have highlighted a central role for draining lymph nodes and environmentally imprinted dendritic cells in the generation of tissue-tropic effector T cells. Here, I outline our current understanding of the mechanisms that regulate the generation and localization of tissue-tropic effector T cells, and the potential ways in which these pathways can be exploited for immunotherapeutic purposes.

PMID:
16932753
DOI:
10.1038/nri1869
[Indexed for MEDLINE]
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