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Neuroreport. 2006 Sep 18;17(13):1443-7.

Postretrieval propranolol disrupts a cocaine conditioned place preference.

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Department of Behavioral Neuroscience, Oregon Health & Science University, Portland Veterans Affairs Medical Center, Portland, Oregon 97239, USA.


The current study examined whether a postretrieval drug memory could be disrupted by the beta-adrenoceptor antagonist propranolol, administered following reactivation in a cocaine-mediated conditioned place preference paradigm. Following cocaine conditioning, rats were given a test of conditioned place preference, followed immediately by intraperitoneal administration of propranolol or saline. Rats that received propranolol following the preference test showed no preference for the cocaine-paired floor during a subsequent test, while vehicle-treated rats continued to express a preference for the cocaine-paired floor. These deficits in behavior were specific to retrieval of the cocaine-mediated memory, suggesting that postretrieval propranolol induced an impairment of drug-seeking behavior that is consistent with the disruption of a reconsolidation phase following retrieval.

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