Format

Send to

Choose Destination
Int J Infect Dis. 2007 Mar;11(2):172-8. Epub 2006 Aug 23.

Circulating Epstein-Barr virus (EBV) in HIV-infected patients and its relation with primary brain lymphoma.

Author information

1
Servicio Virus Oncogénicos, Instituto Nacional de Enfermedades Infecciosas (INEI)- ANLIS Dr. Carlos G. Malbrán, Av. Velez Sársfield 563, C 1282AFF Buenos Aires, Argentina. oncovir1@anlis.gov.ar

Abstract

OBJECTIVE:

To analyze Epstein-Barr virus (EBV) load at different HIV infection stages and its relation with brain lymphoma.

DESIGN:

A cross-sectional study was conducted on 172 HIV-infected individuals: 62 asymptomatic HIV carriers (group A), 30 HIV progressors (group B), 73 AIDS patients (group C), seven AIDS patients with brain lymphoma (group C-BL); and 26 blood donors (group BD) as healthy carriers. EBV load was measured in peripheral blood mononuclear cells (PBMC) and plasma samples using a semi-quantitative PCR method.

RESULTS:

PBMC-EBV levels in HIV-infected patients were higher than in the blood donors (p<0.05). No differences in PBMC-EBV loads were found in groups A, B, or C (p>0.05), while the C-BL group had significantly lower levels (p<0.05). Similar PBMC-EBV loads were seen in HIV-infected patients with CD4+ T cell counts higher than 50/mm(3) (p>0.05), while significantly lower levels were found in cases with less than 50 cells/mm(3) (p<0.05). In all HIV-infected patients, plasma-EBV load was lower than, or similar to, PBMC-EBV load, unlike 2/7 HIV-positive brain lymphoma patients.

CONCLUSIONS:

During HIV infection PBMC-EBV load rises in comparison to healthy carriers, but decreases when immunosuppression progresses and CD4+ T cell count becomes <50/mm(3). Circulating EBV is mainly cell-associated in the HIV-infected population. Neither PBMC-EBV nor plasma-EBV loads would be useful to diagnose brain lymphoma in AIDS patients.

PMID:
16931088
DOI:
10.1016/j.ijid.2006.04.001
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center