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FEBS Lett. 2006 Sep 18;580(21):4996-5002. Epub 2006 Aug 17.

A novel salmonid myoD gene is distinctly regulated during development and probably arose by duplication after the genome tetraploidization.

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Gatty Marine Laboratory, School of Biology, University of St Andrews, St Andrews, Fife, KY16 8LB Scotland, UK.

Erratum in

  • FEBS Lett. 2006 Nov 13;580(26):6286-7.


A novel myoD paralogue was characterised in Salmo salar (smyoD1c) and S. trutta (btmyoD1c). SmyoD1c had 78.2/90.6% protein sequence identity to smyoD1a/smyoD1b, respectively. Each paralogue was differentially expressed throughout somitogenesis. In adult fish, smyoD1a was the predominant gene expressed in fast muscle, whereas smyoD1c was 2-3 times upregulated in slow muscle compared to smyoD1a/1b. A maximum likelihood analysis indicated that myoD1c arose by duplication of myoD1b after the salmonid tetraploidization. Another myoD paralogue (myoD2) is present in at least some teleosts, reflecting a more ancient genome duplication. To accommodate these findings we propose a simplified teleost-myoD nomenclature.

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