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Nat Rev Cancer. 2006 Sep;6(9):714-27.

Comparing antibody and small-molecule therapies for cancer.

Author information

1
Sapporo Medical University, South 1, West 17, Chuo-ku, Sapporo, 060-8556, Japan. imai@sapmed.ac.jp

Abstract

The 'magic bullet' concept of specifically targeting cancer cells at the same time as sparing normal tissues is now proven, as several monoclonal antibodies and targeted small-molecule compounds have been approved for cancer treatment. Both antibodies and small-molecule compounds are therefore promising tools for target-protein-based cancer therapy. We discuss and compare the distinctive properties of these two therapeutic strategies so as to provide a better view for the development of new drugs and the future direction of cancer therapy.

PMID:
16929325
DOI:
10.1038/nrc1913
[Indexed for MEDLINE]

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