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J Neurotrauma. 2006 Aug;23(8):1201-10.

Serum biochemical markers for post-concussion syndrome in patients with mild traumatic brain injury.

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1
Department of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. tomerbegaz@gmail.com

Abstract

Mild traumatic brain injury (MTBI) is a major public health problem in the United States. A significant subset of MTBI patients develop persistent and distressing neurological, cognitive, and behavioral symptoms, known as the post-concussion syndrome (PCS). To date, multiple studies have assessed the relationship between brain-related proteins found in the serum at the time of injury, and the development of PCS. We conducted a systematic review of prospective cohort studies that assessed the ability of serum biochemical markers to predict PCS after MTBI. A total of 11 studies assessing three different potential biochemical markers of PCS--S100 proteins, neuron-specific enolase (NSE), and cleaved Tau protein (CTP)--met selection criteria. Of these markers, S100 appeared to be the best researched. We conclude that no biomarker has consistently demonstrated the ability to predict PCS after MTBI. A combination of clinical factors in conjunction with biochemical markers may be necessary to develop a comprehensive decision rule that more accurately predicts PCS after MTBI.

PMID:
16928178
DOI:
10.1089/neu.2006.23.1201
[Indexed for MEDLINE]
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