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Nat Rev Mol Cell Biol. 2006 Oct;7(10):782-8. doi: 10.1038/nrm2003. Epub 2006 Aug 23.

SUN-domain proteins: 'Velcro' that links the nucleoskeleton to the cytoskeleton.

Author information

1
Department of Genetics, Institute of Life Sciences, Hebrew University of Jerusalem, Givat Ram, Jerusalem 91904, Israel.

Abstract

The novel SUN-domain family of nuclear envelope proteins interacts with various KASH-domain partners to form SUN-domain-dependent 'bridges' across the inner and outer nuclear membranes. These bridges physically connect the nucleus to every major component of the cytoskeleton. SUN-domain proteins have diverse roles in nuclear positioning, centrosome localization, germ-cell development, telomere positioning and apoptosis. By serving both as mechanical adaptors and nuclear envelope receptors, we propose that SUN-domain proteins connect cytoplasmic and nucleoplasmic activities.

PMID:
16926857
DOI:
10.1038/nrm2003
[Indexed for MEDLINE]

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