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Neoplasia. 2006 Aug;8(8):630-44.

Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc.

Author information

1
Department of Biochemistry and Molecular Biology, School of Medicine, Oregon Health and Science University, Portland, OR 97239, USA.

Abstract

Protein ubiquitylation has been demonstrated to play a vital role not only in mediating protein turnover but also in modulating protein activity. The stability and activity of the tumor suppressor p53 and of the oncoprotein c-Myc are no exception. Both are regulated through independent ubiquitylation by several E3 ubiquitin ligases. Interestingly, p53 and c-Myc are functionally connected by some of these E3 enzymes and their regulator ARF, although these proteins play opposite roles in controlling cell growth and proliferation. The balance of this complex ubiquitylation network and its disruption during oncogenesis will be the topics of this review.

PMID:
16925946
PMCID:
PMC1601943
DOI:
10.1593/neo.06334
[Indexed for MEDLINE]
Free PMC Article

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