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Neurology. 2006 Aug 22;67(4):694-6.

Increased rate of whole-brain atrophy over 6 months in early Huntington disease.

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Dementia Research Centre, Institute of Neurology, University College London, London, UK.


The authors measured the rate of whole-brain atrophy over 6 months in 13 patients with early Huntington disease (HD) and seven matched controls. Patients with early HD had significantly increased rates of whole-brain atrophy vs controls (mean [SD] HD, 1.10 [0.88]%/year; controls, 0.26 [0.54]%/year). The measurement of cerebral change over short time periods (e.g., 6 months) may be relevant for trials designed to assess effects on neurodegeneration or atrophy.

[Indexed for MEDLINE]

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