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J Matern Fetal Neonatal Med. 2006 Jul;19(7):415-9.

Neonatal outcome in polycystic ovarian syndrome patients treated with metformin during pregnancy.

Author information

1
Department of Obstetrics and Gynecology, The Edith Wolfson Medical Center, Holon, Israel. michalkovo@hotmail.com

Abstract

OBJECTIVE:

The present study aimed to evaluate the effect of metformin exposure during pregnancy on neonates of polycystic ovarian syndrome (PCOS) patients.

METHOD:

Neonatal outcomes of 33 women with PCOS treated with metformin during pregnancy were compared to neonatal outcomes of 66 normal healthy women in a retrospective case-control study.

RESULTS:

The mean birth weight percentile of neonates exposed to metformin in utero during the first trimester was significantly lower than that of neonates delivered to normal healthy matched controls. After controlling for pregnancy complications, this observation became only marginally statistically significant.

CONCLUSION:

Although metformin is an attractive option for induction of ovulation in PCOS patients, there is a need for more evidence related to its safety during pregnancy.

PMID:
16923696
DOI:
10.1080/14767050600682370
[Indexed for MEDLINE]

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