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Cell. 2006 Aug 25;126(4):655-7.

Improving synaptic function in a mouse model of AD.

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1
Department of Neurology, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.

Abstract

Memory loss is an early symptom of Alzheimer's Disease (AD). The findings of Gong et al. (2006) now indicate that enhancing the activity of UCH-L1, a ubiquitin hydrolase, alleviates the synaptic dysfunction and memory loss associated with a mouse model of AD. This work also raises the question of what role UCH-L1 might play in other diseases involving protein aggregation, such as Parkinson's Disease.

PMID:
16923386
DOI:
10.1016/j.cell.2006.08.011
[Indexed for MEDLINE]
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