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Biochimie. 2007 Jan;89(1):1-20. Epub 2006 Aug 4.

The control of histone lysine methylation in epigenetic regulation.

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1
Institut de Recherche Interdisciplinaire, CNRS FRE 2963, IRI @ Institut de Biologie de Lille, 1, rue du Pr. Calmette, F-59021 Lille Cedex, France.

Abstract

Histone lysine methylation plays a fundamental role in chromatin organization and function. This epigenetic mark is involved in many biological processes such as heterochromatin formation, chromosome X inactivation, genomic imprinting and transcriptional regulation. Here, we review recent advances in how histone lysine methylation participates in these biological events, and the enzymes that control histone lysine methylation and demethylation.

PMID:
16919862
DOI:
10.1016/j.biochi.2006.07.009
[Indexed for MEDLINE]
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