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Chem Biol Interact. 2006 Sep 25;162(3):195-211. Epub 2006 Jul 6.

Structure, function and regulation of carboxylesterases.

Author information

1
Graduate School of Pharmaceutical Sciences, Chiba University, Japan. satohbri@peach.ifnet.or.jp

Abstract

This review covers current developments in molecular-based studies of the structure and function of carboxylesterases. To allay the confusion of the classic classification of carboxylesterase isozymes, we have proposed a novel nomenclature and classification of mammalian carboxylesterases on the basis of molecular properties. In addition, mechanisms of regulation of gene expression of carboxylesterases by xenobiotics and involvement of carboxylesterase in drug metabolism and enzyme induction are also described.

PMID:
16919614
DOI:
10.1016/j.cbi.2006.07.001
[Indexed for MEDLINE]

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