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J Cutan Pathol. 2006 Aug;33(8):581-3.

Squamous cell carcinoma arising in an area of long-standing necrobiosis lipoidica.

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Davies Campbell de Lambert, Rhodes, NSW, Australia.



Squamous cell carcinoma in an area of chronic ulceration is a well-documented phenomenon. However, its occurrence arising de novo in an area of necrobiosis lipoidica is rare.


We report a case in a 53-year-old female who presented with a 2 month history of an erythematous nodule occurring in a plaque of necrobiosis lipoidica on the medical aspect of the right lower leg. She had a background of poorly controlled Type 1 diabetes.


Histopathological findings revealed a well-differentiated squamous cell carcinoma overlying an area of necrobiosis lipoidica. Treatment was by excision and split-thickness skin graft.


Clinicians should be aware of malignant transformation within a plaque of necrobiosis lipoidica. Early detection will allow conservative treatment.

[Indexed for MEDLINE]

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