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Nature. 1990 May 3;345(6270):74-7.

The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion.

Author information

1
Department of Pathology, Harvard Medical School, Boston, Massachusetts.

Abstract

Interaction with antigen-presenting accessory cells is thought to be an important step in B-cell activation, and the B-cell receptor CD22, which is coordinately expressed with surface immunoglobulin, has been proposed to participate in the antigen response. Here we show that CD22 has a structure closely related to myelin-associated glycoprotein (MAG, a neuronal adhesion protein), and mediates monocyte and erythrocyte adhesion. Like CD2, the T-cell erythrocyte receptor, CD22 may facilitate antigen recognition by promoting antigen-nonspecific contacts with accessory cells.

PMID:
1691828
DOI:
10.1038/345074a0
[Indexed for MEDLINE]

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