Alzheimer's disease: the amyloid cascade hypothesis: an update and reappraisal

J Alzheimers Dis. 2006;9(3 Suppl):151-3. doi: 10.3233/jad-2006-9s317.

Abstract

Here I recap the scientific and personal background of the delineation of the amyloid cascade hypothesis for Alzheimer's disease that I wrote with Gerry Higgins and the events leading to the writing of that influential review.

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology*
  • Amyloid beta-Peptides / metabolism*
  • Brain / metabolism*
  • Brain / pathology*
  • Humans

Substances

  • Amyloid beta-Peptides