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Neurology. 2006 Oct 10;67(7):1251-3. Epub 2006 Aug 16.

Pilot clinical trial of gabapentin to decrease postoperative delirium in older patients.

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Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, CA 94143-0648, USA.


In this randomized pilot clinical trial, the authors tested the hypothesis that using gabapentin as an add-on agent in the treatment of postoperative pain reduces the occurrence of postoperative delirium. Postoperative delirium occurred in 5/12 patients (42%) who received placebo vs 0/9 patients who received gabapentin, p = 0.045. The reduction in delirium appears to be secondary to the opioid-sparing effect of gabapentin.

[Indexed for MEDLINE]

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