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Heart. 2007 Feb;93(2):205-9. Epub 2006 Aug 16.

Left ventricular remodelling index (LVRI) in various pathophysiological conditions: a real-time three-dimensional echocardiographic study.

Author information

1
Department of Cardiovascular, Respiratory and Morphological Sciences, La Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy. stefano.decastro@uniroma1.it

Abstract

BACKGROUND:

Various studies have reported a close correlation between real-time three-dimensional echocardiography (RT3DE) and cine magnetic resonance imaging studies for the assessment of cardiac volumes and mass.

OBJECTIVE:

The aim of our study was to evaluate changes in left ventricular volumes and mass in subjects with different pathophysiological conditions. A ratio between left ventricular mass and end-diastolic volume (LVRI), detected by RT3DE, was used to describe various patterns of left ventricular remodelling.

METHODS:

RT3DE was performed to calculate left ventricular end-diastolic (LVEDV) and end-systolic volume (LVESV), ejection fraction (LVEF) and mass in 220 selected subjects. Of these, 152 were healthy volunteers, 19 top-level rowers, 23 patients with dilated cardiomyopathy and 26 patients with hypertrophic cardiomyopathy. Off-line analysis was performed by two independent operators by tracing manual endocardial and epicardial borders of the left ventricle through eight cutting planes. Inter- and intra-observer variability were calculated.

RESULTS:

Despite the increase in LV volume and mass in the rowers, LVRI remained unchanged compared with control subjects (p = 0.455), while significantly lower values were found patients with dilated cardiomyopathy (p<0.001) and significantly higher values in patients with hypertrophic cardiomyopathy (p<0.001). There was inter- and intra-observer variability.

CONCLUSION:

The LVRI may serve as a simple and useful indicator of left ventricular adaptation to physiological and pathological conditions.

PMID:
16914482
PMCID:
PMC1861397
DOI:
10.1136/hrt.2006.093997
[Indexed for MEDLINE]
Free PMC Article

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