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J Neuroimmunol. 2006 Dec;181(1-2):13-8. Epub 2006 Aug 17.

Interferon-gamma down-regulates transcription of the mu-opioid receptor gene in neuronal and immune cells.

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Department of Pharmacology and Toxicology, University of Magdeburg, Leipzigerstr. 44, 39120 Magdeburg, Germany.


Earlier investigations demonstrated up-regulated mu-opioid receptor expression in neuronal and immune cells in response to IL-1, IL-4, IL-6 and TNF-alpha. We herein report that mu-opioid receptor expression is down-regulated in SH SY5Y neuroblastoma cells by IFN-gamma, and that IL-4-mediated induction of mu-opioid receptor expression is inhibited in Jurkat T cells by IFN-gamma. Additionally, mu-opioid receptor transcripts were found in IL-4-expressing human primary T helper cells type 2, but not in type 1 cells, which typically express IFN-gamma. This indicates that mu-opioid receptor expression may be altered under conditions like inflammation, viral infections or neurological diseases associated with imbalanced cytokine expression.

[Indexed for MEDLINE]

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