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Clin Chim Acta. 2007 Feb;376(1-2):37-40. Epub 2006 Jul 14.

Increased insulin sensitivity in intrauterine growth retarded newborns--do thyroid hormones play a role?

Author information

1
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry - 605 006, India.

Abstract

BACKGROUND:

Thyroid hormones are necessary for normal brain development. We studied thyroid hormone profile and insulin sensitivity in intrauterine growth retarded (IUGR) newborns to find correlation between insulin sensitivity and thyroid status in IUGR newborns.

METHODS:

Fifty IUGR and fifty healthy control infants were studied at birth. Cord blood was collected for determination of T(3), T(4), TSH, glucose and insulin levels.

RESULTS:

IUGR newborns had significantly lower insulin, mean+/-S.D., 5.25+/-2.81 vs. 11.02+/-1.85microU/ml, but significantly higher insulin sensitivity measured as glucose to insulin ratio (G/I), 9.80+/-2.91 vs. 6.93+/-1.08 compared to healthy newborns. TSH was also significantly higher 6.0+/-2.70 vs. 2.99+/-1.05microU/ml with significantly lower T(4), 8.65+/-1.95 vs. 9.77+/-2.18microg/dl, but similar T(3) levels, 100.8+/-24.36 vs. 101.45+/-23.45ng/dl. On stepwise linear regression analysis in IUGR infants, insulin sensitivity was found to have a significant negative association with T(4) and significant positive association with TSH.

CONCLUSION:

Thyroid hormones may play a role in increased insulin sensitivity at birth in IUGR.

PMID:
16914130
DOI:
10.1016/j.cca.2006.07.007
[Indexed for MEDLINE]

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