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Factors affecting interictal spike discharges in adults with epilepsy.

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University Hospital, Saskatoon, Sask, Canada.


We investigated various factors affecting interictal spike discharges (ISDs) in standard interictal EEGs of 203 consecutive cases with seizure(s). 94 EEGs (46%) showed ISDs. Yield was maximum (68%) when recordings were done within 2 days of a seizure; beyond this period, incidence of ISD did not change with time from the last seizure. EEGs of patients having greater than 12 seizures/year were more likely to contain ISD (68%) than the records of cases with less than 12 attacks/year (37-41%; P less than 0.001). Age and neurological status at the time of EEG, etiology and anticonvulsants did not influence the frequency of ISD. Analysis of serial EEGs (n = 512) from the study group showed that if initial 3 EEGs lacked ISD, yield from further standard EEGs is small.

[Indexed for MEDLINE]

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