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AIDS Res Hum Retroviruses. 2006 Aug;22(8):709-14.

Molecular epidemiology of HIV Type 1 in Ukraine: birthplace of an epidemic.

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1
U. S. Naval Medical Research Unit No. 3, Cairo, Egypt.

Abstract

During the 1990s, HIV-1 spread rapidly through drug networks in Ukraine and from there throughout the former Soviet Union. To examine the origins of this epidemic, the genetics of HIV-1 in Ukraine were studied. Proviral DNA from PBMC was extracted and PCR amplified. Part of pol and nearly full genomes of HIV-1 were sequenced and characterized. The predominant genetic form in 163 strains was subtype A (66%), followed by subtypes B (30%), C (2%), D (1%), and a new AB recombinant form (1%). HIV strains from Kiev were diverse having subtypes A, B, C, and D. In Crimea, Donetsk, Poltava, and Odessa, however, the strains were overwhelmingly subtype A, while in Nikolaev subtype B predominated. After the near simultaneous introduction of subtypes A and B in Ukraine, subtype B remained where it was introduced while subtype A spread widely, creating the fastest growing epidemic in the world.

PMID:
16910825
DOI:
10.1089/aid.2006.22.709
[Indexed for MEDLINE]

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