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Phytother Res. 2006 Oct;20(10):901-5.

Neuropharmacological evaluation of Ginkgo biloba phytosomes in rodents.

Author information

1
Department of Pharmacology and Toxicology, Principal K. M. Kundnani College of Pharmacy, Jote Joy Building, Rambhau Salgaonkar Marg, Cuffe Parade, Colaba, Mumbai 400 005, India. srnaik5@rediffmail.com

Abstract

On oral administration, Ginkgo biloba phytosomes significantly reduced pentobarbitone-induced sleeping time, produced an alteration in the general behaviour pattern, increased spontaneous motility and inhibited the chlorpromazine-induced blockade of conditioned and unconditioned responses in rodents. They exhibited both antiamnestic and antidepressant activities in the scopolamine-induced amnesia test and behavioural despair test, respectively. However, the phytosomes failed to show anticonvulsant activity. The observations suggest that the G. biloba phytosomes possess moderate antiamnestic/nootropic activity.

PMID:
16909444
DOI:
10.1002/ptr.1973
[Indexed for MEDLINE]
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