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Am J Hum Genet. 2006 Sep;79(3):586-92. Epub 2006 Jul 31.

Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene.

Author information

1
Center for Psychiatric Neuroscience, Lausanne University Hospital, Lausanne, Switzerland. Mirjana.Tosic@chuv.ch

Abstract

Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.

PMID:
16909399
PMCID:
PMC1559555
DOI:
10.1086/507566
[Indexed for MEDLINE]
Free PMC Article
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