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Neuron. 2006 Aug 17;51(4):391-3.

RGS expression level precisely regulates the duration of rod photoresponses.

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  • 1F. M. Kirby Center for Molecular Ophthalmology, University of Pennsylvania, 422 Curie Boulevard, Philadelphia, 19104, USA.


Regulators of G protein signaling (RGS) constitute a family of proteins that bind specifically to the activated alpha subunits of G proteins (Galpha-GTP), acting as GTPase activating proteins, or GAPs, for the rate of GTP hydrolysis. In this issue of Neuron, Krispel et al. resolve a long-standing puzzle in phototransduction, establishing that RGS9 "GAPping" of G(t)alpha-GTP is the molecular mechanism underlying the dominant recovery time constant of mouse rod photoreceptors and that a precise level of expression of RGS9 is required for normal photoresponse timing.

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