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Int J Antimicrob Agents. 2006 Sep;28(3):262-5.

Voriconazole brain tissue levels in rhinocerebral aspergillosis in a successfully treated young woman.

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1st Department of Internal Medicine, University of Cologne, 50924 Cologne, Germany.


Invasive aspergillosis of the central nervous system has a mortality rate exceeding 90%. We describe a 29-year-old woman with a medical history of chronic polyarthritis who developed a proven rhinocerebral Aspergillus fumigatus infection refractory to first-line treatment with liposomal amphotericin B. The patient responded successfully to salvage combination treatment with voriconazole and caspofungin. Furthermore, for the first time, voriconazole levels in an intracerebral abscess were measured in this patient undergoing voriconazole oral therapy.

[Indexed for MEDLINE]

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