Format

Send to

Choose Destination
Biol Cell. 2006 Sep;98(9):557-65.

Positioning centrosomes and spindle poles: looking at the periphery to find the centre.

Author information

1
UMR 144 CNRS/Institut Curie, 26 rue d'Ulm, 75248 Paris cedex 05, France.

Abstract

Centrosome positioning is tightly controlled throughout the cell cycle and probably shares common regulatory mechanisms with spindle-pole positioning. In this article, we detail the possible mechanisms controlling centrosome and spindle positioning in various organisms both in interphase and mitotic cells, and discuss recent findings showing how microtubule plus-end-associated proteins interact with the cell cortex. We suggest that microtubule plus-end complexes simultaneously regulate microtubule dynamics and microtubule anchoring at the cell periphery to allow proper centrosome and spindle-pole positioning.

PMID:
16907664
DOI:
10.1042/BC20060017
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center