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Curr Opin Cell Biol. 2006 Oct;18(5):579-86. Epub 2006 Aug 14.

Integrin structures and conformational signaling.

Author information

1
The CBR Institute for Biomedical Research and Department of Pathology, Harvard Medical School, 200 Longwood Ave, Boston, MA 02115, USA.

Abstract

Integrins are cell adhesion molecules that play critical roles in development, wound healing, hemostasis, immunity and cancer. Advances in the past two years have shed light on the structural basis for integrin regulation and signaling, especially on how global conformational changes between bent and extended conformations relate to the inter-domain and intra-domain shape shifting that regulates affinity for ligand. The downward movements of the C-terminal helices of the alpha I and beta I domains and the swing-out of the hybrid domain play pivotal roles in integrin conformational signaling. Experiments have also shown that integrins transmit bidirectional signals across the plasma membrane by coupling extracellular conformational change with an unclasping and separation of the alpha and beta transmembrane and cytoplasmic domains.

PMID:
16904883
PMCID:
PMC1618925
DOI:
10.1016/j.ceb.2006.08.005
[Indexed for MEDLINE]
Free PMC Article

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