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Methods Find Exp Clin Pharmacol. 1990 Jan-Feb;12(1):43-6.

HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to bacterial penicillin-binding proteins.

Author information

1
Institute of Pharmacology and Biochemistry, University Zürich-Irchel, Switzerland.

Abstract

Penicillin-binding proteins are the specific targets for the beta-lactam antibiotics. Recently it was observed that beta-lactam antibiotics also have targets in proliferating eukaryotic cells (1), one of which most likely is the replicative DNA polymerase alpha. Here we show that HIV-reverse transcriptase and human DNA polymerase alpha share amino acid sequence homologies to five bacterial penicillin-binding proteins.

PMID:
1690323
[Indexed for MEDLINE]

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