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J Occup Environ Med. 2006 Aug;48(8):759-70.

Community exposure to perfluorooctanoate: relationships between serum concentrations and exposure sources.

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  • 1University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104-4284, USA.



The objective of this study was to determine serum (perfluorooctanoate [PFOA]) in residents near a fluoropolymer production facility: the contributions from air, water, and occupational exposures, personal and dietary habits, and relationships to age and gender.


The authors conducted questionnaire and serum PFOA measurements in a stratified random sample and volunteers residing in locations with the same residential water supply but with higher and lower potential air PFOA exposure.


Serum (PFOA) greatly exceeded general population medians. Occupational exposure from production processes using PFOA and residential water had additive effects; no other occupations contributed. Serum (PFOA) depended on the source of residential drinking water, and not potential air exposure. For public water users, the best-fit model included age, tap water drinks per day, servings of home-grown fruit and vegetables, and carbon filter use.


Residential water source was the primary determinant of serum (PFOA).

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