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Eur J Pharmacol. 1990 Jan 10;175(2):203-5.

Caffeine inhibits forskolin-stimulated cyclic AMP accumulation in rat brain.

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Department of Pharmacology, Emory University Medical School, Atlanta, GA 30322.


Caffeine potently inhibited forskolin-stimulated cyclic AMP accumulation in slices of rat cerebral cortex. The IC50 for this inhibition was 21 +/- 2.9 microM, and 200 microM caffeine almost completely blocked the forskolin response. Theophylline which is a behavioural stimulant mimicked the effect of caffeine. However, there was only a slight inhibition of the forskolin response by theobromine and IBMX (3-isobutyl-1-methylxanthine), both of which lack behavioral stimulant effects.

[Indexed for MEDLINE]

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