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Eur J Immunol. 1990 Feb;20(2):337-41.

Human memory T cells express intercellular adhesion molecule-1 which can be increased by interleukin 2 and interferon-gamma.

Author information

1
Macrophage Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London.

Abstract

We have shown that low levels of intercellular adhesion molecule-1 (ICAM-1) expression can be detected on approximately 40% of the resting peripheral blood T cell population. The ICAM-1+ T cells have the phenotypic markers of memory cells which can be distinguished functionally from naive T cells by their ability to respond rapidly to previously experienced antigen. These cells appear to be in a state of marginal activation in that they also express low levels of the interleukin 2 receptor (Tac antigen) and have increased cell size as compared to the naive T cells. In addition we have shown that the cytokines interleukin 2 and interferon-gamma, both of which are products of activated T cells, are able to increase the expression of ICAM-1 on T cells. Finally, pretreating T cells with an anti-ICAM-1 monoclonal antibody inhibits their response to recall antigens, strongly suggesting a functional role for this protein on the memory T cell.

PMID:
1690133
DOI:
10.1002/eji.1830200216
[Indexed for MEDLINE]

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