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Ann Neurol. 2007 Aug;62(2):193-6; discussion 205.

Cystatin C in cerebrospinal fluid and multiple sclerosis.

Author information

1
Department of Clinical Neuroscience, University of Göteborg, Sahlgrenska University Hospital/Mölndal, Mölndal, Sweden.

Abstract

OBJECTIVE:

A recent study using surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid identified a 12.5 kDa truncated isoform of cystatin C (CysC) as a specific biomarker for multiple sclerosis (MS).

METHODS:

Surface-enhanced laser desorption/ionization time-of-flight analysis of cerebrospinal fluid samples from 43 MS patients and 46 healthy control subjects.

RESULTS:

Full-length CysC (13.4 kDa) concentration was similar in MS and control samples. The 12.5 kDa CysC protein was produced from full-length CysC by N-terminal cleavage during storage at -20 degrees C.

INTERPRETATION:

The 12.5 kDa CysC isoform is a storage-related artifact and is not useful as a diagnostic marker for MS.

PMID:
16900522
DOI:
10.1002/ana.20945
[Indexed for MEDLINE]

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