Selective radiosensitization by nitric oxide in tumor cell lines

Cancer Lett. 2007 Apr 8;248(1):123-30. doi: 10.1016/j.canlet.2006.06.009. Epub 2006 Aug 8.

Abstract

The radiosensitizing effect of nitric oxide (NO) on mouse and human tumor cells with different degrees of malignancy was evaluated. Cells pre-treated with the NO donor diethylenetriamine-NO (DETA-NO), were irradiated with gamma rays. Survival curves were obtained by clonogenicity and fitted to the linear-quadratic model. Results demonstrated an association between radiosensitization and degree of malignancy. The more malignant the cell line, the higher the degree of radiosensitization by DETA-NO. In conclusion, the differential radiosensitizing effect of DETA-NO shown here is of great interest for the potential use of NO in radiotherapy, due to an enhanced radiation effect on tumor vs. normal tissue.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Line, Tumor
  • Cell Proliferation / drug effects*
  • Cell Proliferation / radiation effects*
  • Cell Survival / drug effects
  • Cell Survival / physiology
  • Cell Survival / radiation effects
  • Dose-Response Relationship, Radiation
  • Gamma Rays
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Nitric Oxide / physiology*
  • Nitric Oxide Donors / pharmacology
  • Triazenes / pharmacology*

Substances

  • 1-hydroxy-2-oxo-3,3-bis(2-aminoethyl)-1-triazene
  • Nitric Oxide Donors
  • Triazenes
  • Nitric Oxide