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Org Lett. 2006 Aug 17;8(17):3623-6.

Synthesis and characterization of glucosamine-bound near-infrared probes for optical imaging.

Author information

1
JHU ICMIC Program, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.

Abstract

[structure: see text] Two novel near-infrared (NIR) fluorescent probes have been synthesized by linking a carbocyanine fluorophore and glucosamine through different linkers. These probes demonstrated a high quantum yield, low cytotoxicity, reversible pH-dependent fluorescence in the physiological pH range, and a decreased aggregation tendency in aqueous solutions. In vitro NIR optical imaging studies revealed cellular uptake and strong intracellular NIR fluorescence of these two probes in four breast epithelial cell lines.

PMID:
16898776
DOI:
10.1021/ol060783e
[Indexed for MEDLINE]
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