Format

Send to

Choose Destination
See comment in PubMed Commons below
Nature. 1990 Mar 8;344(6262):126-32.

In vivo alteration of telomere sequences and senescence caused by mutated Tetrahymena telomerase RNAs.

Author information

1
Department of Molecular and Cell Biology, University of California, Berkeley.

Abstract

Mutating the CAACCCCAA sequence in the RNA component of telomerase causes the synthesis in vivo of new telomere sequences corresponding to the mutated RNA sequence, demonstrating that the telomerase contains the template for telomere synthesis. These mutations also lead to nuclear and cell division defects, and senescence, establishing an essential role for telomerase in vivo.

PMID:
1689810
DOI:
10.1038/344126a0
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center