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Biotechnol Bioeng. 2006 Oct 20;95(3):533-8.

Selective detection and transport of fully matched DNA by DNA-loaded microtubule and kinesin motor protein.

Author information

1
Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, AIST, Central 6, 1-1-1 Higashi, Tsukuba 305-8566, Japan.

Abstract

DNA-loaded microtubules (MTs) moving on a kinesin motor protein-coated substrate can selectively hybridize with a target fully matched DNA over single-base mismatched DNA and transport it. This technique is capable of collecting target biomolecules toward one point site to design new methodology of DNA analysis.

PMID:
16897728
DOI:
10.1002/bit.21055
[Indexed for MEDLINE]

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