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Nat Rev Microbiol. 2006 Sep;4(9):660-9. Epub 2006 Aug 7.

Fundamental processes in the evolutionary ecology of Lyme borreliosis.

Author information

1
Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath, BA2 7AY, UK. kk221@bath.ac.uk

Abstract

The evolutionary ecology of many emerging infectious diseases, particularly vector-borne zoonoses, is poorly understood. Here, we aim to develop a biological, process-based framework for vector-borne zoonoses, using Borrelia burgdorferi sensu lato (s.l.), the causative agent of Lyme borreliosis in humans, as an example. We explore the fundamental biological processes that operate in this zoonosis and put forward hypotheses on how extrinsic cues and intrinsic dynamics shape B. burgdorferi s.l. populations. Additionally, we highlight possible epidemiological parallels between B. burgdorferi s.l. and other vector-borne zoonotic pathogens, including West Nile virus.

PMID:
16894341
DOI:
10.1038/nrmicro1475
[Indexed for MEDLINE]
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