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Nat Rev Microbiol. 2006 Sep;4(9):710-6. Epub 2006 Aug 7.

Breaching the great wall: peptidoglycan and microbial interactions.

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  • 1Department of Plant Pathology, University of Wisconsin, 1630 Linden Drive, Madison, Wisconsin 53706, USA.


Once thought to be a process that occurred only in a few human pathogens, release of biologically active peptidoglycan fragments during growth by Gram-negative bacteria controls many types of bacterial interaction, including symbioses and interactions between microorganisms. This Perspective explores the role of peptidoglycan fragments in mediating a range of microbial-host interactions, and discusses the many systems in which peptidoglycan fragments released during bacterial growth might be active.

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