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Neurology. 2006 Aug 8;67(3):494-6.

Immunologic diseases, anti-inflammatory drugs, and Parkinson disease: a case-control study.

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Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.


The authors studied the association of markers of inflammation with the later development of Parkinson disease (PD) using a case-control design (196 cases and 196 matched controls). The frequency of diseases of immediate-type hypersensitivity was significantly higher in cases than controls. In addition, cases used anti-inflammatory agents less frequently than controls (nonsignificant trend). The results may support the hypothesis that there is an inflammatory component in the pathogenesis of PD.

[Indexed for MEDLINE]

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