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Crit Rev Microbiol. 2006;32(3):139-53.

Streptococcus pneumoniae protein vaccine candidates: properties, activities and animal studies.

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Department of Microbiology, College of Medicine, Howard University, Washington, DC 20059, USA.


Streptococcus pneumoniae is a causative agent for community acquired pneumonia, bacteremia, acute otitis media, and meningitis. Recent emergence of multi-drug resistant clinical isolates prompts the need of effective vaccine for the prevention of disease. The licensed polysaccharide-based pneumococcal vaccines only elicit protective antibodies against the infection of serotypes that are included in the vaccine. To broaden the protection, the use of pneumococcal proteins will be a feasible and preferable alternative. This communication provides a review on the biochemical properties of these protein candidates, their immunization results in animal studies, and perspectives on the development of protein-based pneumococcal vaccine.

[Indexed for MEDLINE]

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