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Exp Cell Res. 2006 Aug 15;312(14):2677-86. Epub 2006 Jun 30.

Chromatin modulation and the DNA damage response.

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1
Genome Stability Laboratory, Department of Biochemistry and National Centre for Biomedical Engineering Science, National University of Ireland, Galway.

Abstract

The ability to sense and respond appropriately to genetic lesions is vitally important to maintain the integrity of the genome. Emerging evidence indicates that various modulations to chromatin structure are centrally important to many aspects of the DNA damage response (DDR). Here, we discuss recently described roles for specific post-translational covalent modifications to histone proteins, as well as ATP-dependent chromatin remodelling, in DNA damage signalling and repair of DNA double strand breaks.

PMID:
16893724
DOI:
10.1016/j.yexcr.2006.06.031
[Indexed for MEDLINE]
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