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Exp Cell Res. 2006 Aug 15;312(14):2641-6. Epub 2006 Jun 20.

Cellular senescence and DNA repair.

Author information

1
Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA.

Abstract

Aging is a complex process that results in functional decline and mortality of the organisms. On the cellular lever, cellular senescence has been used as a model for aging. Therefore, understanding cellular senescence has important health implications. Initial observations suggest that cellular senescence is the result of telomere shortening. Recent findings suggest that cellular senescence could be triggered by DNA damage. In fact, both telomere shortening and DNA-damage-induced cellular senescence share a common mechanism, the DNA damage response pathway. This review will discuss the link between DNA repair defects and cellular senescence.

PMID:
16893723
DOI:
10.1016/j.yexcr.2006.06.009
[Indexed for MEDLINE]

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