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Nat Cell Biol. 2006 Sep;8(9):1032-4. Epub 2006 Aug 6.

Smc5-Smc6 mediate DNA double-strand-break repair by promoting sister-chromatid recombination.

Author information

1
Cell Cycle Group, MRC Clinical Sciences Centre, Imperial College London, Du Cane Road, London W12 0NN, UK.

Abstract

DNA double-strand breaks (DSB) can arise during DNA replication, or after exposure to DNA-damaging agents, and their correct repair is fundamental for cell survival and genomic stability. Here, we show that the Smc5-Smc6 complex is recruited to DSBs de novo to support their repair by homologous recombination between sister chromatids. In addition, we demonstrate that Smc5-Smc6 is necessary to suppress gross chromosomal rearrangements. Our findings show that the Smc5-Smc6 complex is essential for genome stability as it promotes repair of DSBs by error-free sister-chromatid recombination (SCR), thereby suppressing inappropriate non-sister recombination events.

PMID:
16892052
PMCID:
PMC4493748
DOI:
10.1038/ncb1466
[Indexed for MEDLINE]
Free PMC Article

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