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Curr Opin Gastroenterol. 2006 Sep;22(5):505-11.

Key role of Krüppel-like factor proteins in pancreatic cancer and other gastrointestinal neoplasias.

Author information

1
Gastroenterology Research Unit, Saint Mary's Hospital, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

Abstract

PURPOSE OF REVIEW:

To describe recent studies on Krüppel-like factor transcription factors and their relationship with gastrointestinal neoplasias, in particular pancreatic cancer.

RECENT FINDINGS:

Krüppel-like factor proteins are a subfamily of transcription factors characterized by the presence of a conserved DNA-binding domain comprising three Krüppel-like zinc fingers. Each distinct family member differs in its ability to regulate transcription, and, as a consequence, to influence cellular processes including cell growth and differentiation. Recently, a number of publications have provided evidence of the implication of Krüppel-like factor proteins in gastrointestinal carcinogenesis.

SUMMARY:

This article will focus on the results of studies in the field published in the last year.

[Indexed for MEDLINE]

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