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J Antimicrob Chemother. 2006 Oct;58(4):802-5. Epub 2006 Aug 5.

Pharmacodynamics of dalbavancin studied in an in vitro pharmacokinetic system.

Author information

1
Bristol Centre for Antimicrobial Research & Evaluation, North Bristol NHS Trust and University of Bristol Bristol, UK.

Abstract

OBJECTIVES:

The antibacterial effect of dalbavancin was studied against Staphylococcus aureus using stepwise declining concentrations designed to model a range of free drug concentrations observed in human serum.

METHODS:

Initial concentrations ranged from 0.6 to 21 mg/L and experiments were conducted over 240 h. Three vancomycin-susceptible and one vancomycin-intermediate strain of S. aureus were used.

RESULTS AND CONCLUSIONS:

Dalbavancin showed non-concentration-dependent killing against the three vancomycin-susceptible strains in the range 3-21 mg/L and the vancomycin-intermediate strain at 15 and 21 mg/L. AUC/MIC could be related to antibacterial effect. The AUC/MIC for a bacteriostatic effect was 36 at 24 h, 55 at 120 h and 100 at 240 h. A larger AUC/MIC was required to produce a 2 log reduction in counts, being 214 at 24 h, 195 at 120 h and 331 at 240 h.

PMID:
16891629
DOI:
10.1093/jac/dkl311
[Indexed for MEDLINE]

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