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J Allergy Clin Immunol. 2006 Aug;118(2):389-95. Epub 2006 May 30.

Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice.

Author information

1
Physiology Program, Department of Environmental Health, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA. sshore@hsph.harvard.edu

Abstract

BACKGROUND:

Epidemiologic data indicate an increased incidence of asthma in the obese.

OBJECTIVE:

Because serum levels of the insulin-sensitizing and anti-inflammatory adipokine adiponectin are reduced in obese individuals, we sought to determine whether exogenous adiponectin can attenuate allergic airway responses.

METHODS:

We sensitized and challenged BALB/cJ mice with ovalbumin (OVA). Alzet micro-osmotic pumps were implanted in the mice to deliver continuous infusions of buffer or adiponectin (1.0 microg/g/d), which resulted in an approximate 60% increase in serum adiponectin levels. Two days later, mice were challenged with aerosolized saline or OVA once per day for 3 days. Mice were examined 24 hours after the last challenge.

RESULTS:

OVA challenge increased airway responsiveness to intravenous methacholine, bronchoalveolar lavage fluid cells, and T(H)2 cytokine levels. Importantly, each of these responses to OVA was reduced in adiponectin- versus buffer-treated mice. OVA challenge caused a 30% reduction in serum adiponectin levels and a corresponding decrease in adipose tissue adiponectin mRNA expression. OVA challenge also decreased pulmonary mRNA expression of each of 3 proposed adiponectin-binding proteins, adiponectin receptor 1, adiponectin receptor 2, and T-cadherin.

CONCLUSION:

Our results indicate that serum adiponectin is reduced during pulmonary allergic reactions and that adiponectin attenuates allergic airway inflammation and airway hyperresponsiveness in mice.

CLINICAL IMPLICATIONS:

The data suggest that adiponectin might play a role in the relationship between obesity and asthma.

PMID:
16890763
DOI:
10.1016/j.jaci.2006.04.021
[Indexed for MEDLINE]

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