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Curr Biol. 2006 Aug 8;16(15):R585-8.

Neural coding: hybrid analog and digital signalling in axons.

Author information

1
Wolfson Institute for Biomedical Research and Department of Physiology, University College London, Gower Street, London WC1E 6BT, UK.

Abstract

Mammalian axons are thought to act as digital signaling devices, conveying information only by the timing and rate of all-or-none action potentials. Two recent studies now show that synaptic potentials can also spread far down the axon and influence action potential-triggered transmitter release in a graded, 'analog' manner. Axons thus encode information both about subthreshold and suprathreshold synaptic activity.

PMID:
16890514
DOI:
10.1016/j.cub.2006.07.007
[Indexed for MEDLINE]
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